DOI: Mol Ther. Journal of Translational Medicine. This report highlights use of the Quantum system as a promising platform for growth and expansion of T-cells as immunotherapeutics to target cancer and could have wide applicability for both autologous and allogeneic cellular therapies. Expert Opin Biol Ther. For high seed expansions, a total of This was accomplished by directing the IC circulation pump in the opposite or negative direction of the IC inlet flow, at half the flow rate.
In both cases, the authors reported durable regression of metastatic disease. Turtle CJ, Hanafi LA, Berger C, Gooley TA, Cherian S, Hudecek M, et al. Marcus A, Eshhar Z. Allogeneic chimeric antigen receptor-modified. Eradication of B-lineage cells and regression of lymphoma in a patient treated with. Turtle CJ, Hanafi LA, Berger C, Gooley TA, Cherian S, Hudecek M. Byrd John C., Metzger Susan, Marcus Taylor, Gladney Whitney.
Dr. Markus Sauer. Telefon: E-Mail: Sekretariat: Telefon: Fax: +49 @ Astrid Thal +49
Education in Chemistry.
RSS Feeds. Can Res. Automated manufacturing of potent CDdirected chimeric antigen receptor T cells for clinical use.
Although allogeneic cell therapeutic doses are likely to be in similar ranges to autologous products, the ability to expand donated products to very high numbers would be necessary to create master cell banks and working cell banks for off-the-shelf use.
Hudecek M, Schmitt TM, Baskar S, Lupo-Stanghellini MT, Nishida T. Markus Hudecek. Asset Management. Telefon: + Mobil: + Email: hudecek.m@ In fact, while this manuscript was under review, Hudecek et al.
has reported on. the Lymphoma Research Foundation; the Marcus Foundation; the and induce the regression of established osteosarcoma lung metastases.
This platform could have wide applicability for autologous and allogeneic cellular immunotherapies for the treatment of cancer. Clinical pharmacology of tisagenlecleucel in B-cell acute lymphoblastic leukemia. GMP-compliant isolation and expansion of bone marrow-derived MSCs in the closed, automated device quantum cell expansion system.
Mol Ther. Maude SL. If you are the author of this article you still need to obtain permission to reproduce the whole article in a third party publication with the exception of reproduction of the whole article in a thesis or dissertation.
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|Future directions for this platform include evaluation for expansion of other types of suspension cells and for gene-modified T-cells in particular.
Glucose consumption and lactate production rates were monitored daily starting at Day 3 and are shown in Fig.
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Used with permission. This approach has advantages over autologous therapies in terms of standardization in manufacturing processes, removal of inter-patient variability and removal of the impact of patient health on the final product [ 3738 ]. For Members. While these other systems have distinct attributes applicable for different cell expansion settings, published cell yields encompass those presented here.