Pittella JEH. Sequencing of the T. The species Trypanosoma cruzi is a heterogeneous population composed of diverse strains circulating in nature, with genetic variability observed among them This way many proteins may be specifically associated to their phylogenetic subdivisions, thus being used as specific biomarkers of the pathogen subspecies 90and helping to find the possible causes for the clinical variability of the disease. Nat Rev Genet.
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The trypanosome transcriptome is remodelled during differentiation but displays limited responsiveness within life stages. Learn the latest Get instant insight into what people are talking about now.
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For instance, genes in amastigotes and epimastigotes proliferative phases were enriched in those involved in DNA repair. They have proteases and accumulate proteins from endocytosis Rev Inst Med Trop.
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Functional analysis of Trypanosoma brucei PUF1. Proteomics of trypanosomatids of human medical importance. Rochette, et al.
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Additionally, it was recently demonstrated using genetically modified fluorescent protozoa, that the epimastigote forms are also infective 62, There are more thanindividuals chronically infected by T. Developmental stages of trypanosomatid flagellates: A new terminology.